In very rare instances, people who suspect their fathers, brothers or other family members are long-sought serial killers are dead right and help authorities solve a notorious cold case. But far more often, they pester police with circumstantial evidence backing up wild theories.

The double murder of hitchhikers Vicki Durian and Nancy Santomero in the summer of 1980 shook Pocahontas County, West Virginia. Nearly 40 years later, the Appalachian community is still haunted by the unsolved case, now known as the 'Rainbow Murders.'

Family annihilation—wherein men kill their wives and kids (and, more often than not, themselves)—is so grotesque that it feels like it should only happen when a person is blinded by anger. But Chris Watts didn't murder his family in a fit of rage. We explore how his case breaks the family annihilator pattern.

If you fill a prison with the nation’s most dangerous people, that prison, naturally, will be a dangerous place. And even with Alcatraz Federal Penitentiary's notoriously strong security, those people occasionally strike with sensational violence. We look at some of the most grisly murders that took place at the hands of inmates at 'The Rock.'

When new evidence arises, or new technology becomes available, investigators may need to take a second look at a corpse.

On February 2, 2008, a man walked into a woman's clothing store in Chicago and shot and killed five women. It's one of the worst mass murders in the city's history, and the murderer is still on the loose.

In the early 1970s, Rochester, New York was plagued by a series of unsolved child murders. The three victims each had alliterative names and the killings became known as the 'double initial' or 'alphabet' murders. Will the killer or killers ever be found?

Genealogical DNA databases are helping solve more cold cases. We explore why that could be problematic.

A&E True Crime takes a look at some of the most notable 'black widows,' and the unbelievable lengths they went to off their spouses.

A&E True Crime explores the stories of five young women who were vital members of Charles Manson's cult, 'The Family,' and what became of them after they were separated from the man who had so thoroughly dominated their psyches.